| OFLOXACIN |
| C.A.S No. |
82419-36-1 |
| Molecular weight |
361.37 |
| Molecular formula |
C18H20FN3O4 |
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Chemical Name |
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(+/-)-9-Fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4- benzoxazine-6-carboxylic acid. |
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Synonyms |
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OFLX; Floxin; (+/-)-Ofloxacin |
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TEST |
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SPECIFICATIONS |
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Description |
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A pale yellow or bright yellow crystalline powder |
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Solubility |
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Glacial Acetic acid. - Soluble
Water, Methanol, Methylene chloride. -Slightly Soluble |
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Identification
By IR absorption |
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The infrared absorption spectrum of the finely ground sample in KBr dispersion compressed into a disk should exhibit maxima only at the same wave lengths as that of a similar preparation of Working standard. |
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Light absorption at
440nm/ 1 cm |
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Not more than 0.25
(0.5% w/v Solution in 0.1 M Hydrochloric acid) |
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Loss on Drying |
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Not more than 0.2% W/W |
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Sulphated ash |
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Not more than 0.1% W/W |
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Heavy metals |
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Not more than 10 ppm |
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Purity by HPLC |
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Maximum single impurity: Not more than 0.5%
Total Impurity: Not more than 1.0 % |
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Titrimetric Assay (on dry basis) |
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Not less then 98.5% and Not more than 101.5% |
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| USES |
Ofloxacin is used in the treatment of typhoid fever, community acquired pneumonia, pelvic inflammatory disease (PID), non gonococcus urethritis, Prostatitis, urinary tract infections (UTI), bacterial conjunctivitis, corneal ulcers, ear infections etc. |
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