| SERTRALINE HCL |
| C.A.S No. |
79559-97-0 |
| Molecular Formula |
C17H17Cl2N.HCl |
| Chemical Name |
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine Hydrochloride |
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Test |
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Specification |
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Description |
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Off-White to white crystalline powder. |
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Solubility |
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Sparingly Soluble in Methanol. Slightly soluble in Dimethyl formamide |
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Identification By HPLC |
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The IR spectrum of sample d should be concordant with the spectrum of reference standard |
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Melting Range |
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Between 240 - 250°C |
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Loss On Drying |
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Not More Than 0.50 % w/w |
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Sulphated Ash |
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Not More Than 0.10 % w/w |
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Heavy Metals |
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Not More Than 10 ppm |
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Sp. Optical Rotation (C=0. 05N Methanolic Acid) |
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+ 38 to + 42° |
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Related substances by HPLC
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Single Impurity |
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NMT 0.20% |
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Total Impurities |
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NMT 0.50% |
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Assay (on anhydrous basis) |
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Not Less than 98.0% and Not More Than 102.0% |
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Residual solvents |
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Methanol Not More Than 2000 ppm |
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Ethylacetate Not More Than 3000 ppm |
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| USES |
Sertraline is used to treat depression, panic attacks, obsessive compulsive disorders (OCD), and post-traumatic stress disorder (PTSD). This medication works by helping to restore the balance of certain natural chemicals in the brain. This medication has also been used to treat a severe form of premenstrual syndrome (premenstrual dysphoric disorder- PMDD) and a sexual function problem in men (premature ejaculation |
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